| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 5 | Second XI | 1980-11-15 | Murrumbeena | lost to | Brunswick District |
| 134 R Coghill 33 M O'Neill 36* | | 179 G Burns 5/29 S Goold 3/46 J Crombie 2/55
and 1/32 |
| 6 | First XI | 1980-11-29 | Murrumbeena |  | Hampton |
| 123
and 6/85 P Hay 44* | | 116 J Graham 7/35 A Graham 2/22
and 5/108 P Way 2/27 |
| 7 | First XI | 1980-12-20 | East Malvern | def | Murrumbeena |
| 3/162 D Hardham 2/18 | | 68 |
| 8 | First XI | 1981-01-17 | Murrumbeena | lost to | South Caulfield |
| 83 | | 5/124 P Way 3/38 |
| 9 | First XI | 1981-01-24 | Altona North | def | Murrumbeena |
| 254 A Graham 2/56 P Way 4/28 | | 147 D Hardham 31 |
| 10 | Second XI | 1981-01-26 | Highett | def | Murrumbeena |
| 9/145 A Read 5/25 G Hay 2/30 G Burns 2/20 | | 8/121 S Hay 44* |
| 12 | Second XI | 1981-02-21 | Altona North | | Murrumbeena |
| 105 A Roach 3/36 R Parker 4/29 | | 183 G Russell 34 M O'Neill 62
and 1/46 |
